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FTIR based kinetic characterisation of an acid-catalysed esterification of 3-methylphthalic anhydride and 2-ethylhexanol

Abstract

In this study, an inline analytical method was designed and applied in process characterisation and development. The model reaction is the two-step diesterification of 3-methylphthalic anhydride with 2-ethylhexanol consisting of alcoholysis as first step, followed by an acid-catalysed, second esterification step leading to the corresponding diester. The final product is a potential, alternative plasticizer. For the inline measurements, attenuated total reflection Fourier transformed infrared spectroscopy (ATR-FTIR) was implemented. In order to evaluate the spectra recorded during the reaction, a chemometric model was established. In this work, Indirect Hard Modeling (IHM), a non-linear modeling approach was employed. The respective model was calibrated by offline samples analyzed with gas (GC) and liquid chromatography (HPLC). After successful validation of the chemometric model, the inline measurements were utilized for reaction characterisation. The acid-catalysed, second esterification step was indentified as limiting reaction step. From batch reactions conducted at different temperatures, the energy of activation of this step was determined to 79.5 kJ mol-1. Additionally, kinetics was shown to follow a pseudo-first order with respect to the monoesters formation and a kinetic model was established. The model was validated in simulations with changed reaction conditions.

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Article information


Submitted
03 Apr 2020
Accepted
09 May 2020
First published
14 May 2020

Anal. Methods, 2020, Accepted Manuscript
Article type
Paper

FTIR based kinetic characterisation of an acid-catalysed esterification of 3-methylphthalic anhydride and 2-ethylhexanol

R. Hiessl, L. Hennecke, C. M. T. Plass, J. Kleber, S. Wahlefeld, R. Otter, H. Gröger and A. Liese, Anal. Methods, 2020, Accepted Manuscript , DOI: 10.1039/D0AY00686F

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