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Issue 21, 2020
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Paper-based fluorogenic RNA aptamer sensors for label-free detection of small molecules

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Abstract

Sensors based on fluorogenic RNA aptamers have emerged in recent years. These sensors have been used for in vitro and intracellular detection of a broad range of biological and medical targets. However, the potential application of fluorogenic RNA-based sensors for point-of-care testing is still little studied. Here, we report a paper substrate-based portable fluorogenic RNA sensor system. Target detection can be simply performed by rehydration of RNA sensor-embedded filter papers. This affordable sensor system can be used for the selective, sensitive, and rapid detection of different target analytes, such as antibiotics and cellular signaling molecules. We believe that these paper-based fluorogenic RNA sensors show great potential for point-of-care testing of a wide range of targets from small molecules, nucleic acids, proteins, to various pathogens.

Graphical abstract: Paper-based fluorogenic RNA aptamer sensors for label-free detection of small molecules

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Supplementary files

Article information


Submitted
22 Mar 2020
Accepted
06 May 2020
First published
20 May 2020

Anal. Methods, 2020,12, 2674-2681
Article type
Paper

Paper-based fluorogenic RNA aptamer sensors for label-free detection of small molecules

F. Shafiei, K. McAuliffe, Y. Bagheri, Z. Sun, Q. Yu, R. Wu and M. You, Anal. Methods, 2020, 12, 2674
DOI: 10.1039/D0AY00588F

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