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A facile ratiometric electrochemical sensor for sensitive 4-Acetamidophenol determination based on ferrocene-graphene oxide -nafion modified electrode

Abstract

A ratiometric electrochemical sensor was constructed for sensitive 4-Acetamidophenol (4-AP) detection. Ferrocene (Fc) attached on the self assembly of graphene oxide (GO) which occurred to form GO-Fc complex with electrostatic interactions. Furthermore, nafion was added into the complex in a certain ratio for immobilizing. The GO-Fc-nafion complex was drop-coated on the surface of a glassy carbon electrode (GCE) to prepare GO-Fc-nafion/GCE sensing platform. There was a strong, plotted linear relationship between I4-AP /IFc and 4-AP concentration in the range from 1 to 100 μM, with a low detection limit of 0.2μM. This fabricated ratiometric electrochemical sensing platform exhibited high sensitivity and stability responses towards 4-AP, over potential interferences. Experimental results confirmed high detection stability and recoveries, indicating its high feasibility for 4-AP detection in biological samples.

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Article information


Submitted
08 Jan 2020
Accepted
12 Feb 2020
First published
12 Feb 2020

Anal. Methods, 2020, Accepted Manuscript
Article type
Paper

A facile ratiometric electrochemical sensor for sensitive 4-Acetamidophenol determination based on ferrocene-graphene oxide -nafion modified electrode

H. Guo, Z. Wang, W. Yang, J. Li and D. Jiang, Anal. Methods, 2020, Accepted Manuscript , DOI: 10.1039/D0AY00028K

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