Electropolymerization of chitosan in the presence of CuNPs on the surface of copper electrode: An advanced nanocomposite for determination of mefenamic acid and indomethacin in human plasma samples and prevention of drug poisonings
An innovative method for the electro-polymerization of chitosan on the surface of copper electrode was introduced. Two electrochemical sensors for the measurements of indomethacin and mefenamic acid in human plasma samples were constructed based on copper nanoparticles (CuNPs) and poly chitosan modified by CuNPs, respectively. Electrochemical behavior of the CuNPs modified copper electrode (CuE) and poly-chitosan doped by CuNPs modified copper electrode (P(CS)-CuNPs-CuE) were investigated using differential pulse voltammetry and cyclic voltammetry techniques. Electrochemical results show that, CuNPs and P(CS)- CuNPs led to increased oxidation peak current, by adsorption of indomethacin. According to the obtained results, the linear range and low limit of quantification (LLOQ) were obtained as 1 nM-10 mM and 1 nM, respectively.