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A supramolecular probe of cyanine dye for Pb2+ detection based on the recognition of a G-quadruplex from DNA duplexes

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Abstract

Herein, we carried out the supramolecular self-assembly of cyanine dye (MTC) for the transformation between duplex DNA and G-quadruplex (T30695) for the highly selective and sensitive recognition of Pb2+ ions via UV-vis spectroscopy. A specific duplex DNA (duplex-a) consisting of a Pb2+ aptamer and its part complementary strand was constructed, which could be unwound to single-strand DNA to form a G-quadruplex in the presence of Pb2+. The formed G-quadruplex could transform MTC H-aggregates into monomers, resulting in a specific recognition absorption signal.

Graphical abstract: A supramolecular probe of cyanine dye for Pb2+ detection based on the recognition of a G-quadruplex from DNA duplexes

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Article information


Submitted
13 Nov 2019
Accepted
10 Jan 2020
First published
10 Jan 2020

Anal. Methods, 2020, Advance Article
Article type
Communication

A supramolecular probe of cyanine dye for Pb2+ detection based on the recognition of a G-quadruplex from DNA duplexes

L. Yu, H. Zhao, N. Jing, X. Shi, Y. Zhang, C. Ding, Y. Zhang, J. Fan and Y. Tang, Anal. Methods, 2020, Advance Article , DOI: 10.1039/C9AY02446H

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