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Mesoporous yolk–shell structure molecularly imprinted magnetic polymers for the extraction and detection of 17β-estradiol

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Abstract

Novel mesoporous yolk–shell structure magnetic molecularly imprinted polymers (MYS-MMIPs) were synthesized via surface polymerization using E2 as a template followed by chemical selective etching to remove the inorganic silica interlayer for the rapid, selective extraction and sensitive detection of 17β-estradiol (E2) in milk powder. For MYS-MMIPs, transmission electron microscopy coupled with N2 adsorption experiments confirmed the successful formation of a mesoporous yolk–shell structure. Furthermore, the thermogravimetric and recycling experiments showed the good thermal and adsorption stability of MYS-MMIPs, the magnetic properties experiment confirmed their good magnetic response, and the binding experiment indicated their selective recognition and high binding capacity (39.24 mg g−1) for E2. The obtained polymers were applied as adsorbents for the magnetic solid phase extraction (MSPE) of E2. After optimizing the MSPE conditions, an MSPE-HPLC method was developed for the determination of E2 in milk powder. The linear range was 1–300 μg kg−1 with a limit of detection of 0.33 μg kg−1. The satisfactory recoveries ranged from 88.3–102.4% and the relative standard deviations (RSDs) were lower than 5.5%. Thus, the MSPE-HPLC method has high accuracy and sensitivity for the analysis of E2 in milk samples.

Graphical abstract: Mesoporous yolk–shell structure molecularly imprinted magnetic polymers for the extraction and detection of 17β-estradiol

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Article information


Submitted
01 Nov 2019
Accepted
09 Dec 2019
First published
13 Dec 2019

Anal. Methods, 2020, Advance Article
Article type
Paper

Mesoporous yolk–shell structure molecularly imprinted magnetic polymers for the extraction and detection of 17β-estradiol

Y. Yang, Y. Sun, H. Chen, X. Dang, Y. Ai, X. Liu and H. Chen, Anal. Methods, 2020, Advance Article , DOI: 10.1039/C9AY02360G

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