A multi-photon fluorescent probe based on quinoline groups for the highly selective and sensitive detection of lipid droplets

Sijing Zhang; Zhenghui Yang; Minghao Li; Qiong zhang; Xiaohe Tian; Dandan Li; Shengli Li; Jieying Wu; Yupeng Tian

doi:10.1039/D0AN01847C

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A multi-photon fluorescent probe based on quinoline groups for the highly selective and sensitive detection of lipid droplets†

Sijing Zhang,‡^a Zhenghui Yang,‡^b Minghao Li,‡^a Qiong zhang,

*^a Xiaohe Tian,

^b Dandan Li,

^c Shengli Li,^a Jieying Wu^a and Yupeng Tian

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230601, P. R. China
E-mail: zhangqiong.314@163.com, yptian@ahu.edu.cn

^b School of Life Science, Anhui University, Hefei 230039, P. R. China

^c Institutes of Physics Science and Information Technology, Anhui University, Hefei 230039, P. R. China

Abstract

Compared to general fluorescent probes, multi-photon fluorescent probes exhibit deeper tissue penetration, lower auto-fluorescence and lower photo-toxicity in the bio-imaging field. Herein, we synthesized a series multi-photon fluorescent probe (L1–L3) based on quinolone groups. Of notably, the three-photon fluorescence of L3 significantly enhanced when L3 interacted with liposome; moreover, L3 exhibited high selectivity towards lipid droplets in living cells. Due to its large Stokes shift, high selectivity and photon-stability, L3 was successfully used in lipid droplet imaging via multi-photon fluorescence bio-imaging.

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DOI: https://doi.org/10.1039/D0AN01847C
Article type: Paper
Submitted: 15 Sep 2020
Accepted: 21 Sep 2020
First published: 24 Sep 2020

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Analyst, 2020,145, 7941-7945

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A multi-photon fluorescent probe based on quinoline groups for the highly selective and sensitive detection of lipid droplets

S. Zhang, Z. Yang, M. Li, Q. zhang, X. Tian, D. Li, S. Li, J. Wu and Y. Tian, Analyst, 2020, 145, 7941 DOI: 10.1039/D0AN01847C

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A multi-photon fluorescent probe based on quinoline groups for the highly selective and sensitive detection of lipid droplets†

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A multi-photon fluorescent probe based on quinoline groups for the highly selective and sensitive detection of lipid droplets

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