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A multi-photon fluorescent probe based on quinoline groups for the highly selective and sensitive detection of lipid droplets

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Abstract

Compared to general fluorescent probes, multi-photon fluorescent probes exhibit deeper tissue penetration, lower auto-fluorescence and lower photo-toxicity in the bio-imaging field. Herein, we synthesized a series multi-photon fluorescent probe (L1–L3) based on quinolone groups. Of notably, the three-photon fluorescence of L3 significantly enhanced when L3 interacted with liposome; moreover, L3 exhibited high selectivity towards lipid droplets in living cells. Due to its large Stokes shift, high selectivity and photon-stability, L3 was successfully used in lipid droplet imaging via multi-photon fluorescence bio-imaging.

Graphical abstract: A multi-photon fluorescent probe based on quinoline groups for the highly selective and sensitive detection of lipid droplets

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Supplementary files

Article information


Submitted
15 Sep 2020
Accepted
21 Sep 2020
First published
24 Sep 2020

Analyst, 2020, Advance Article
Article type
Paper

A multi-photon fluorescent probe based on quinoline groups for the highly selective and sensitive detection of lipid droplets

S. Zhang, Z. Yang, M. Li, Q. zhang, X. Tian, D. Li, S. Li, J. Wu and Y. Tian, Analyst, 2020, Advance Article , DOI: 10.1039/D0AN01847C

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