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A cytosolically localized far-red to near-infrared rhodamine-based fluorescent probe for calcium ions

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Abstract

Ca2+ is one of the most important second messengers in cells. A far-red to near-infrared (NIR) Ca2+ fluorescent probe is useful for multi-color imaging in GFP or YFP-expressing biosamples. Here we developed a cytosolically localized far-red to NIR rhodamine-based fluorescent probe for Ca2+, CaSiR-2 AM, while rhodamine dyes are basically localized to mitochondria or lysosomes in cells.

Graphical abstract: A cytosolically localized far-red to near-infrared rhodamine-based fluorescent probe for calcium ions

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Article information


Submitted
31 Aug 2020
Accepted
22 Sep 2020
First published
23 Sep 2020

Analyst, 2020, Advance Article
Article type
Paper

A cytosolically localized far-red to near-infrared rhodamine-based fluorescent probe for calcium ions

K. Numasawa, K. Hanaoka, T. Ikeno, H. Echizen, T. Ishikawa, M. Morimoto, T. Komatsu, T. Ueno, Y. Ikegaya, T. Nagano and Y. Urano, Analyst, 2020, Advance Article , DOI: 10.1039/D0AN01739F

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