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Integrating nucleic acid sequence-based amplification and microlensing for high-sensitivity self-reporting detection

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Abstract

We use electron-beam patterned functional microgels to integrate self-reporting molecular beacons, dielectric microlenses, and solid-phase and/or solution-phase nucleic acid amplification in a viral-detection microarray model. The detection limits for different combinations of these elements range from 10−10 M for direct target-beacon hybridization alone to 10−18 M when all elements are integrated simultaneously.

Graphical abstract: Integrating nucleic acid sequence-based amplification and microlensing for high-sensitivity self-reporting detection

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Article information


Submitted
19 Jun 2020
Accepted
15 Sep 2020
First published
16 Sep 2020

Analyst, 2020, Advance Article
Article type
Communication

Integrating nucleic acid sequence-based amplification and microlensing for high-sensitivity self-reporting detection

F. Teng, X. Wu, T. Hong, G. B. Munk and M. Libera, Analyst, 2020, Advance Article , DOI: 10.1039/D0AN01231A

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