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Issue 21, 2020
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A bifunctional DNA probe for sensing pH and microRNA using a nanopore

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Abstract

We have developed a bifunctional probe based on triplex molecular beacons for the measurement of environmental pH and quantification of microRNA-10b using a nanopore. The probe responds sharply to solution pH changes in the range of 6.0–7.5. The limit of detection for microRNA-10b is as low as 5.0 pM.

Graphical abstract: A bifunctional DNA probe for sensing pH and microRNA using a nanopore

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Supplementary files

Article information


Submitted
16 Jun 2020
Accepted
09 Aug 2020
First published
10 Aug 2020

Analyst, 2020,145, 7025-7029
Article type
Paper

A bifunctional DNA probe for sensing pH and microRNA using a nanopore

Y. Zhang, P. Song, B. Guo, W. Hao, L. Liu and H. Wu, Analyst, 2020, 145, 7025
DOI: 10.1039/D0AN01208D

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