Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



A ratiometric fluorescent probe for imaging of enzyme dependent hydrogen sulfide variation in mitochondria and in living mice

Abstract

Developing ratiometric H2S fluorescent probe with fast response is of great importance for studying the H2S physiology. Herein, two hemicyanine based H2S probes were constructed, the one with a propanoic acid group (CouPa) showed poor sensitivity while the other one with N,N-diethylpropionamide moiety (CouDE) exhibited distinctly improved performance. CouDE showed the ability to detect mitochondria H2S level fluctuation, which was triggered by alteration of CBS enzyme activity. Moreover, endogenous H2S change in solid tumours was monitored using CouDE.

Back to tab navigation

Supplementary files

Article information


Submitted
06 May 2020
Accepted
29 Jun 2020
First published
30 Jun 2020

Analyst, 2020, Accepted Manuscript
Article type
Communication

A ratiometric fluorescent probe for imaging of enzyme dependent hydrogen sulfide variation in mitochondria and in living mice

Y. Zhang, Y. Chen, H. Fang, X. Shi, H. Yuan, B. Yang, W. He and Z. Guo, Analyst, 2020, Accepted Manuscript , DOI: 10.1039/D0AN00910E

Social activity

Search articles by author

Spotlight

Advertisements