Surface-Enhanced Laser Desorption/Ionization Mass Spectrometry for Rapid Analysis of Organic Environmental Pollutants by Using Polydopamine Nanospheres as Substrate
Polydopamine nanospheres (PDA) was designed to serve as a new substrate for surface-enhanced desorption/ionization mass spectrometry (SELDI-MS). In comparasion with conventional organic matrices, the PDA substrate showed superior LDI performance in the analysis of a wide varity of environmental pollutants including polycyclic aromatic hydrocarbons, bisphenols, benzophenones, sulfonamides, perfluorinated compounds and estrogens. Benzoapyrene was used to evaluate the ability of quantitative analysis and its corresponding limit of detection (LOD) as low as 0.1 ng was achieved. High sensitivity and good reproducibility of PDA-based SELDI-MS were allowed to determine ultratrace PAHs in airborne particulate matters (PM2.5) and the corresponding concentration of BaP in different PM2.5 were 5.32, 8.97 and 9.79 ng m-3, respectively. Significantly, PDA exhibit the characteristics of simple synthesis, low cost, non-toxicity and less matrix interference, which provides the possibility of sensitive analysis of low concentration organic small molecule pollutants in complex environmental samples.