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Herein, we present an approach to design a fluorescent molecule for detection and discrimination of fluoride-containing G series and sulfur-containing V series nerve agents. FP1 bearing two reactive groups can react with fluorides and thiols from the two types of nerve agents and generate different products with obvious and diverse fluorescences, which will be helpful when dealing with terrorist crises.

Graphical abstract: A fluorescent probe bearing two reactive groups discriminates between fluoride-containing G series and sulfur-containing V series nerve agents

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