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Highly efficient enrichment of N-glycopeptides by two-dimensional Hf-based metal–organic framework nanosheets

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Abstract

Highly efficient enrichment of target glycopeptides plays a crucial role in glycoproteome research. Owing to their large surface area and excellent hydrophilicity, 2-D Hf-BTB nanosheets showed effective and selective enrichment of 78 glycopeptides derived from 29 glycoproteins with 90 N-glycosylation sites from just 2 μL of human serum.

Graphical abstract: Highly efficient enrichment of N-glycopeptides by two-dimensional Hf-based metal–organic framework nanosheets

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Article information


Submitted
02 Apr 2020
Accepted
18 May 2020
First published
19 May 2020

Analyst, 2020, Advance Article
Article type
Communication

Highly efficient enrichment of N-glycopeptides by two-dimensional Hf-based metal–organic framework nanosheets

S. Yang, C. Wang, J. Xiao, X. Yu, W. Shang, D. D. Y. Chen and Z. Gu, Analyst, 2020, Advance Article , DOI: 10.1039/D0AN00647E

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