Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 21st October 2020 from 07:00 AM to 07:00 PM (BST).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 15, 2020
Previous Article Next Article

Luminescent probes for hypochlorous acid in vitro and in vivo

Author affiliations

Abstract

HClO/ClO is the most effective antibacterial active oxygen in neutrophils. However, its excessive existence often leads to the destruction of human physiological mechanisms. In recent years, the developed luminescent probes for the detection of HClO/ClO are not only conducive to improve the sensitivity and selectivity of HClO/ClO detection, but also play a crucial role in understanding the biological functions of HClO/ClO. In addition, luminescent probe-based biological imaging for HClO/ClO at sub-cellular resolution has become a powerful tool for biopathology and medical diagnostic research. This article reviews a variety of luminescent probes for the detection of HClO/ClOin vitro and in vivo with different design principles and mechanisms, including fluorescence, phosphorescence, and chemiluminescence. The photophysical/chemical properties and biological applications of these luminescent probes were outlined. Finally, we summarized the merits and demerits of the developed luminescent probes and discussed their challenges and future development trends. It is hoped that this review can provide some inspiration for the development of luminescent probe-based strategies and to promote the further research of biomedical luminescent probes for HClO/ClO.

Graphical abstract: Luminescent probes for hypochlorous acid in vitro and in vivo

Back to tab navigation

Article information


Submitted
02 Apr 2020
Accepted
10 Jun 2020
First published
10 Jun 2020

Analyst, 2020,145, 5068-5089
Article type
Critical Review

Luminescent probes for hypochlorous acid in vitro and in vivo

S. Dong, L. Zhang, Y. Lin, C. Ding and C. Lu, Analyst, 2020, 145, 5068
DOI: 10.1039/D0AN00645A

Social activity

Search articles by author

Spotlight

Advertisements