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Microfluidic device fabrication mediated by surface chemical bonding

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Abstract

This review discusses various bonding strategies for fabricating microfluidic devices, with a special emphasis on the modification of the surface assisted by the use of chemicals to assemble microfluidic devices under mild conditions such as room temperature and atmospheric pressure. The paper includes an overview of the wide ranges of bonding methods used in the fabrication of microfluidic systems, such as anodic bonding, fusion bonding, thermal bonding, solvent bonding, and surface chemical bonding. Among these, surface chemical bonding plays a crucial role between the polydimethylsiloxane (PDMS) and thermoplastics in order to assemble a microfluidic device in a simple and facile manner. The first section reviews relevant research on the sealing for microfluidic devices; in the second section, the materials used for device fabrication are reviewed. The third section discusses the different sealing processes used in the fabrication of microfluidic devices on silicon, glass, thermoplastic, and elastomer. Overall, this review concludes with a discussion on the importance of the surface chemical modification for bonding an elastomer – PDMS – with rigid materials at room temperature under atmospheric pressure and detailed discussions on their bond strengths.

Graphical abstract: Microfluidic device fabrication mediated by surface chemical bonding

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Article information


Submitted
30 Mar 2020
Accepted
10 May 2020
First published
13 May 2020

Analyst, 2020, Advance Article
Article type
Tutorial Review

Microfluidic device fabrication mediated by surface chemical bonding

R. Sivakumar and N. Y. Lee, Analyst, 2020, Advance Article , DOI: 10.1039/D0AN00614A

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