Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Acid–base titration using a microfluidic thread-based analytical device (μTAD)

Author affiliations

Abstract

This work presents the development and application of a novel analytical approach for the determination of acid and base concentrations by titration using a microfluidic thread-based analytical device (μTAD). This approach proved to be a simple to fabricate and to use, high precision, and cost-efficient means of acid–base quantification. The μTAD was fabricated by immobilizing the untreated cotton threads onto a wood frame, followed by pre-coating with an indicator (20 μL) and a primary standard solution (3 μL), and was tested using real samples including drug, food, and household products where 3 μL of each sample was dropped onto the center of a thread. Afterward, the distance of color change on the thread, easily observed and measured using the naked eye and a ruler, was used for analysis. The analysis using the μTAD, completed within 2 minutes and validated by the conventional titration, showed high accuracy and precision (RSD < 12.9%), good linearity ranges and low limit of quantification. The fabricated μTAD also remained stable for an extended period of time (>2 weeks under various storage conditions).

Graphical abstract: Acid–base titration using a microfluidic thread-based analytical device (μTAD)

Back to tab navigation

Supplementary files

Article information


Submitted
14 Mar 2020
Accepted
04 May 2020
First published
04 May 2020

Analyst, 2020, Advance Article
Article type
Paper

Acid–base titration using a microfluidic thread-based analytical device (μTAD)

P. Jarujamrus, A. Prakobkij, S. Puchum, S. Chaisamdaeng, R. Meelapsom, W. Anutrasakda, M. Amatatongchai, S. Chairam and D. Citterio, Analyst, 2020, Advance Article , DOI: 10.1039/D0AN00522C

Social activity

Search articles by author

Spotlight

Advertisements