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Snake venom characteristic peptides: novel fingerprints for species identification by sheathless capillary electrophoresis-electrospray ionization-mass spectrometry

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Abstract

Snake venom is a complex mixture mainly consisting of proteins and peptides which varies with different species. These variations lead to different toxic mechanisms and different anti-venom serums for treatment and the determination of their use as drugs. Hence, it is important to develop a sensitive and reliable method to identify the species of snakes from venoms. Herein, we present a novel strategy based on the sheathless capillary electrophoresis-electrospray ionization-mass spectrometry (CESI-MS) system to characterize snake venom proteins. Through the determination of peptides, we found the characteristic peptides of 8 different snakes with high sensitivity (1 μg mL−1) and high selectivity, which provided a reliable method for the species identification and purity detection of snake venom samples.

Graphical abstract: Snake venom characteristic peptides: novel fingerprints for species identification by sheathless capillary electrophoresis-electrospray ionization-mass spectrometry

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Article information


Submitted
06 Mar 2020
Accepted
21 May 2020
First published
21 May 2020

Analyst, 2020, Advance Article
Article type
Paper

Snake venom characteristic peptides: novel fingerprints for species identification by sheathless capillary electrophoresis-electrospray ionization-mass spectrometry

Y. Liu, X. Zhang, Y. Yu, H. Chen, Y. Zhou and X. Zhang, Analyst, 2020, Advance Article , DOI: 10.1039/D0AN00461H

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