Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Gold alloy-based nanozyme sensor arrays for biothiol detection

Author affiliations

Abstract

Biothiols play an important role in living cells and are associated with many diseases. Thus, it is necessary to develop a facile, cost-effective, and convenient analytical method for the detection of biothiols. Nanozymes are functional nanomaterials with enzymatic activities. Due to their unique advantages (e.g., low cost, high stability, and multifunctionality), nanozymes have been extensively used to construct sensing systems. Previous studies demonstrated colorimetric assays for biothiol detection because they could competitively inhibit the peroxidase-like activities of nanozymes. However, few studies were able to differentiate biothiols from each other. To address these challenges, herein, we first synthesized Au alloy nanozymes with better peroxidase-like activities than gold nanoparticles (AuNPs). Then, cross-reactive sensor arrays were constructed with three alloy nanozymes. Six typical biothiols (i.e., glutathione, cysteine, dithiothreitol, mercaptoacetic acid, mercaptoethanol, and mercaptosuccinic acid) were successfully detected and discriminated by the as-prepared nanozyme sensor arrays. Moreover, the practical application of the nanozyme sensor arrays was demonstrated by discriminating biothiols in serum successfully.

Graphical abstract: Gold alloy-based nanozyme sensor arrays for biothiol detection

Back to tab navigation

Associated articles

Supplementary files

Article information


Submitted
04 Mar 2020
Accepted
25 Mar 2020
First published
25 Mar 2020

Analyst, 2020, Advance Article
Article type
Paper

Gold alloy-based nanozyme sensor arrays for biothiol detection

J. Lin, Q. Wang, X. Wang, Y. Zhu, X. Zhou and H. Wei, Analyst, 2020, Advance Article , DOI: 10.1039/D0AN00451K

Social activity

Search articles by author

Spotlight

Advertisements