Jump to main content
Jump to site search


Gold Alloy-Based Nanozyme Sensor Arrays for Biothiols Detection

Abstract

Biothiols play an important role in living cells and are associated with many diseases. Thus, it is necessary to develop a facile, cost-effective, and convenient analytical method for detection of biothiols. Nanozymes are functional nanomaterials with enzymatic activities. Due to their unique advantages (e.g., low cost, high stability, and multifunctionality), nanozymes have been extensively used to construct sensing systems. Previous studies demonstrated colorimetric assays for biothiols detection because they could competitively inhibit the peroxidase-like activities of nanozymes. However, few studies were able to differentiate biothiols from each other. To address these challenges, herein, we first synthesized Au alloy nanozymes with better peroxidase-like activities than gold nanoparticles (AuNPs). Then, cross-reactive sensor arrays were constructed with three alloy nanozymes. Six typical biothiols (i.e., glutathione, cysteine, dithiothreitol, mercaptoacetic acid, mercaptoethanol, and mercaptosuccinic acid) were successfully detected and discriminated by the as-prepared nanozyme sensor arrays. Moreover, the practical application of the nanozyme sensor arrays was demonstrated by discriminating biothiols in serum successfully.

Back to tab navigation

Supplementary files

Article information


Submitted
04 Mar 2020
Accepted
25 Mar 2020
First published
25 Mar 2020

Analyst, 2020, Accepted Manuscript
Article type
Paper

Gold Alloy-Based Nanozyme Sensor Arrays for Biothiols Detection

J. Lin, Q. Wang, X. Wang, Y. Zhu, X. Zhou and H. Wei, Analyst, 2020, Accepted Manuscript , DOI: 10.1039/D0AN00451K

Social activity

Search articles by author

Spotlight

Advertisements