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Lipidomic Profiling of Virus Infection Identifies Mediators that Resolve Herpes Simplex Virus-Induced Corneal Inflammatory Lesions

Abstract

Lipid mediators( LMs) play a pivotal role in the induction and resolution of inflammation. To identify and elucidate their involvement during virus infection, Multiple Reaction Monitoring (MRM) based liquid chromatography -tandem mass spectrometry lipidomic profiling of 62 lipid species was performed in this study. Results show that RAW264.7 macrophages differentially produce specific LMs signals depending on different virus pathogenicity. Integration of the large-scale lipidomics with targeted gene expression data revealed mediators, such as RVD3,18-HEPE,11(12)-EET et al. correlated with the pathogenic phase of the infection. The Herpes Simplex Virus(HSV)-induced keratitis model demonstrates that 11(12)-EET treatment represents a novel alternative for treating viral infection.

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Article information


Submitted
07 Feb 2020
Accepted
18 Mar 2020
First published
24 Mar 2020

Analyst, 2020, Accepted Manuscript
Article type
Paper

Lipidomic Profiling of Virus Infection Identifies Mediators that Resolve Herpes Simplex Virus-Induced Corneal Inflammatory Lesions

C. Zhang, Z. Hu, K. Wang, L. Yang, Y. Ni, H. Schlüter, P. Yang, J. Hong and H. Yu, Analyst, 2020, Accepted Manuscript , DOI: 10.1039/D0AN00263A

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