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A mitochondria-targeted fluorescent probe for hypochlorite sensing and its application in bioimaging

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Abstract

A coumarin-diaminomaleonitrile derivative (C-DAN) was designed and prepared. Upon addition of hypochlorite (OCl), the fluorescence emission peak of C-DAN at 475 nm was gradually enhanced with a rapid response (within 5 s); meanwhile, the color of the solution changed from dark red to bright yellow which can be observed with the naked eye. Furthermore, owing to its advantages including high selectivity, sensitivity, and low toxicity, our C-DAN probe has been applied for detecting OCl in living cells and zebrafish, indicating it is an ideal tool for biological applications.

Graphical abstract: A mitochondria-targeted fluorescent probe for hypochlorite sensing and its application in bioimaging

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Supplementary files

Article information


Submitted
05 Feb 2020
Accepted
03 Mar 2020
First published
04 Mar 2020

Analyst, 2020, Advance Article
Article type
Paper

A mitochondria-targeted fluorescent probe for hypochlorite sensing and its application in bioimaging

Q. Yang, X. Zhong, Y. Chen, J. Yang, C. Jin and Y. Jiang, Analyst, 2020, Advance Article , DOI: 10.1039/D0AN00245C

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