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An ultrasensitive electrochemiluminescence aptasensor for the detection of diethylstilbestrol based on the enhancing mechanism of the metal–organic framework NH2-MIL-125(Ti) in a 3,4,9,10-perylenetetracarboxylic acid/K2S2O8 system

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Abstract

In this work, a sensitive and selective electrochemiluminescent aptasensor was proposed based on the enhancing mechanism of the metal–organic framework NH2-MIL-125(Ti) in a 3,4,9,10-perylenetetracarboxylic acid/K2S2O8 system for a diethylstilbestrol assay. Herein, 3,4,9,10-perylenetetracarboxylic acid was selected as the major luminophore, and the metal–organic framework NH2-MIL-125(Ti) displayed a large specific surface area to immobilize abundant PTCA molecules to facilitate electrochemiluminescence efficiency. Besides, the metal–organic framework NH2-MIL-125(Ti) was used as a novel catalyst in the 3,4,9,10-perylenetetracarboxylic acid/K2S2O8 system, which could react with the co-reactant K2S2O8 to produce more SO4˙. In addition, we introduced the amino-aptamer of diethylstilbestrol; due to the specific binding affinity between the aptamer and diethylstilbestrol, a selective electrochemiluminescent aptasensor for diethylstilbestrol was thus developed here. Under the optimal conditions, a wide detection range from 1.0 fM to 1.0 μM with a low detection limit of 0.28 fM (S/N = 3) was obtained. More importantly, the residual diethylstilbestrol in water was detected by the developed aptasensor; this confirmed that this method has good performance and potential applications in real samples.

Graphical abstract: An ultrasensitive electrochemiluminescence aptasensor for the detection of diethylstilbestrol based on the enhancing mechanism of the metal–organic framework NH2-MIL-125(Ti) in a 3,4,9,10-perylenetetracarboxylic acid/K2S2O8 system

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Article information


Submitted
01 Feb 2020
Accepted
06 Mar 2020
First published
07 Mar 2020

Analyst, 2020, Advance Article
Article type
Paper

An ultrasensitive electrochemiluminescence aptasensor for the detection of diethylstilbestrol based on the enhancing mechanism of the metal–organic framework NH2-MIL-125(Ti) in a 3,4,9,10-perylenetetracarboxylic acid/K2S2O8 system

J. Li, X. Shan, D. Jiang and Z. Chen, Analyst, 2020, Advance Article , DOI: 10.1039/D0AN00212G

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