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Application of a Y-type-DNA-functionalized nanogold probe featuring specific telomerase recognition and doxorubicin release in cancer cells

Abstract

A Y-type-DNA-functionalized nanogold probe was synthesized to identify telomerase and trigger drug release in cancer cells. This system involved a DNA-functionalized nanogold probe centering on gold nanoparticles with dense modification of Y-type DNA molecular beacons on the surface. The Y-type DNA molecular beacon consisted of the telomerase primers (TP), FAM-labeled single-strand DNA (Mismatch-DNA), and single- strand DNA of two templates (Linker-DNA1,Linker-DNA2). Doxorubicin (Dox), an anti-cancer drug molecule, was inserted into DNA double strands. When telomerase existed, TP was extended, Mismatch-DNA was released, leading to emition of fluorescent light from the FAM while releasing Dox. This probe specifically detected cancer cells and did not affect normal cells. This drug delivery system will reduce tumour size and cause minimal injury to normal tissues.

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Supplementary files

Article information


Submitted
30 Dec 2019
Accepted
10 Feb 2020
First published
14 Feb 2020

Analyst, 2020, Accepted Manuscript
Article type
Paper

Application of a Y-type-DNA-functionalized nanogold probe featuring specific telomerase recognition and doxorubicin release in cancer cells

S. Zhang, K. Liang, P. Li, J. Liu and B. Tang, Analyst, 2020, Accepted Manuscript , DOI: 10.1039/C9AN02630D

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