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Silicotungstic acid as a highly efficient coreactant for luminol chemiluminescence for sensitive detection of uric acid

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Abstract

Herein, we report luminol–silicotungstic acid (STA) chemiluminescence (CL) for the first time. The luminol–STA system resulted in remarkable CL enhancement (65 times) compared with the known classical luminol–H2O2 system because of the generation of the strong oxidizing agent tungsten trioxide from STA. Based on the quenching effect of uric acid, the new CL system is applied for the sensitive and selective assay of uric acid in its pure state (LOD 0.75 nM) and in real human urine with excellent recoveries in the range of 99.6–102.3%. Furthermore, this system permits the efficient detection of STA (LOD, 0.24 μM).

Graphical abstract: Silicotungstic acid as a highly efficient coreactant for luminol chemiluminescence for sensitive detection of uric acid

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Supplementary files

Article information


Submitted
23 Dec 2019
Accepted
09 Feb 2020
First published
10 Feb 2020

Analyst, 2020, Advance Article
Article type
Paper

Silicotungstic acid as a highly efficient coreactant for luminol chemiluminescence for sensitive detection of uric acid

I. M. Mostafa, M. I. Halawa, Y. Chen, A. Abdussalam, Y. Guan and G. Xu, Analyst, 2020, Advance Article , DOI: 10.1039/C9AN02600B

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