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Unusual "OFF-ON" fluorescent sensor including a triazole unit for Al3+ detection via selective imine hydrolysis and its cell image study

Abstract

Monitoring of excess Al3+ in biological and environmental samples is major goal for scientists due to its harmful effects. Thus, the development of selective and convenient techniques for Al3+ recognition is essential. Herein, we present the design of new fluorescent molecule A1 for the recognition of Al3+. The results indicated that the recognition mechanism of imine hydrolysis of A1 for Al3+ was exactly different from other many Al3+ probes working with chelation enhanced fluorescence. A1 demonstrated highly selective fluorescent response in "OFF-ON" mode toward the presence of Al3+ over a pool of analyte including 18 cations with striking blue emission. Moreover, it has prominent LOD value (0.117 µM), fast response time (10 s) and linear emission increase relationship with Al3+ concentration (0-20.0 M). Bioimaging studies in human colorectal carcinoma (DLD-1) and healthy epithelial cells (CCD-18Co) demonstrated excellent results. The performance of A1 toward Al3+ proved that it could be exploited as a signal tool for environmental and biological samples

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Supplementary files

Article information


Submitted
11 Dec 2019
Accepted
22 Mar 2020
First published
24 Mar 2020

Analyst, 2020, Accepted Manuscript
Article type
Paper

Unusual "OFF-ON" fluorescent sensor including a triazole unit for Al3+ detection via selective imine hydrolysis and its cell image study

S. Erdemir, S. Karakurt and S. Malkondu, Analyst, 2020, Accepted Manuscript , DOI: 10.1039/C9AN02500F

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