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A sensitive “ON-OFF” fluorescent probe based on carbon dots for Fe2+ detection and cell imaging

Abstract

Fe2+ is a trace metal ion required by the human body, and its abnormal metabolism can cause serious diseases. Herein, we report the development of a highly efficient "ON-OFF" fluorescent probe based on carbon dots (CDs), prepared by a simple one-step hydrothermal method. The CDs exhibited exceptional water dispersibility and stability, superior luminescence performance as well as low cytotoxicity. The fluorescence could be efficiently quenched by Fe2+ through electronic transfer process. And under the optimized experimental conditions, this probe shows excellent selectivity and high sensitivity for Fe2+ with a detection limit of 51 nmol. More interestingly, this probe could realize the visual detection of Fe2+ when Fe3+ and Cu2+ ions were efficiently shielded by tartaric acid in the presence of ascorbic acid. Furthermore, the developed fluorescent probe has been successfully applied for the detection of Fe2+ in tap water and BSA solution as well as for biosensing of Fe2+ in living cells. Key words: Fluorescent probe, Carbon dots, Fe2+, Visual detection, Cell imaging

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Supplementary files

Article information


Submitted
16 Nov 2019
Accepted
11 Jan 2020
First published
14 Jan 2020

Analyst, 2020, Accepted Manuscript
Article type
Paper

A sensitive “ON-OFF” fluorescent probe based on carbon dots for Fe2+ detection and cell imaging

S. Wei, L. Tan, X. Yin, R. Wang, X. Shan, Q. Chen, T. Li, X. zhang, C. Jiang and G. Sun, Analyst, 2020, Accepted Manuscript , DOI: 10.1039/C9AN02309G

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