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An ultrasensitive and selective fluorescent nanosensor based on porphyrinic metal–organic framework nanoparticles for Cu2+ detection

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Abstract

Detecting trace amounts of copper ions (Cu2+) is of high importance since copper is an essential element in the environment and the human body. Despite the recent advances in Cu2+ detection, the current approaches still suffer from insensitivity and lack of in situ detection in living cells. In the present work, a fluorescent nanosensor based on porphyrinic metal–organic framework nanoparticles (MOF-525 NPs) is proposed for sensitive and selective monitoring of Cu2+ in aqueous solution and living cells. The MOF-525 NPs with attractive properties, including ultrasmall size, good water dispersity and intense red fluorescence, are prepared via a facile and environment-friendly hydrothermal route. The fluorescence signal of MOF-525 NPs could be quenched statically by Cu2+ with high selectivity due to the strong affinity of Cu2+ to the porphyrin ligand in MOF-525. The proposed fluorescent nanosensor has a linear response in the range of 1.0–250 nM with a low detection limit of 220 pM. Furthermore, it is successfully employed for the detection of Cu2+ in water samples and the intracellular imaging of Cu2+ in living cells, demonstrating its great potential in the sensing and biological fields.

Graphical abstract: An ultrasensitive and selective fluorescent nanosensor based on porphyrinic metal–organic framework nanoparticles for Cu2+ detection

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Article information


Submitted
07 Nov 2019
Accepted
17 Dec 2019
First published
17 Dec 2019

Analyst, 2020, Advance Article
Article type
Paper

An ultrasensitive and selective fluorescent nanosensor based on porphyrinic metal–organic framework nanoparticles for Cu2+ detection

C. Cheng, R. Zhang, J. Wang, Y. Zhang, C. Wen, Y. Tan and M. Yang, Analyst, 2020, Advance Article , DOI: 10.1039/C9AN02231G

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