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Nanomolar detection of biothiols via turn-ON fluorescent indicator displacement

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Abstract

The thiol group is known to have a high affinity for gold nanoparticles and is capable of displacing other capping agents. We report a fluorescent indicator displacement technique for the detection of biothiols based on this principle. The displacement of BODIPY from the surface of gold nanoparticles served as a sensitive method for the detection of cysteine, homocysteine, and glutathione under a variety of conditions. It is noteworthy that the turn-ON fluorescence mechanism enabled the differentiation of normal cells from cancer cells because of the inherently higher concentrations of biothiols in the latter.

Graphical abstract: Nanomolar detection of biothiols via turn-ON fluorescent indicator displacement

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Article information


Submitted
06 Nov 2019
Accepted
10 Dec 2019
First published
10 Dec 2019

Analyst, 2020, Advance Article
Article type
Paper

Nanomolar detection of biothiols via turn-ON fluorescent indicator displacement

P. P. Praveen Kumar, N. Kaur, A. Shanavas and P. P. Neelakandan, Analyst, 2020, Advance Article , DOI: 10.1039/C9AN02222H

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