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A paper-based biosensor for visual detection of glucose-6-phosphate dehydrogenase from whole blood

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Abstract

Screening for a deficiency of glucose-6-phosphate dehydrogenase (G6PD) in red blood cells is vital for determining the potentially life-threatening presence of congenital, hereditary or induced hemolytic anemias. In this study, a “sample-to-readout” paper-based point-of-care (POC) colorimetric biosensor was developed for direct detection of G6PD in whole blood by simple visual comparison to a color card. The G6PD paper sensor was highly stable with no observable loss in performance after room temperature storage for at least 6 weeks, and worked equally well at room temperature and 37 °C. The simple printed paper format and the stability of the colorimetric reagents facilitates scalable manufacturing. The ability to utilize well established sample collection and preparation protocols along with a colorimetric visual readout should facilitate future transfer of this proof-of-concept POC biosensor to remote or resource-poor locations.

Graphical abstract: A paper-based biosensor for visual detection of glucose-6-phosphate dehydrogenase from whole blood

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Supplementary files

Article information


Submitted
05 Nov 2019
Accepted
07 Jan 2020
First published
20 Jan 2020

Analyst, 2020, Advance Article
Article type
Paper

A paper-based biosensor for visual detection of glucose-6-phosphate dehydrogenase from whole blood

D. White, M. Keramane, A. Capretta and J. D. Brennan, Analyst, 2020, Advance Article , DOI: 10.1039/C9AN02219H

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