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Issue 5, 2020
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Spectroelectrochemical and computational studies of tetrahydrocannabinol (THC) and carboxy-tetrahydrocannabinol (THC-COOH)

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Abstract

Rapid and accurate detection of tetrahydrocannabinol (THC) and its main secondary metabolite carboxy-tetrahydrocannabinol (THC-COOH) is important to ensure safe roadways and workplaces, particularly in regions of the world where cannabis use is legal. In this work, we seek to demonstrate the usefulness of electrochemical SERS (EC-SERS) for the rapid detection of both THC and THC-COOH, complemented by thorough ab initio calculations for both molecules. These results indicate that application of a voltage is essential for efficient SERS detection of cannabinoids at low concentrations in bodily fluids, allowing for the eventual development of sensitive and quantitative screening tools. To the best of our knowledge, this work represents the first EC-SERS study of both THC and THC-COOH.

Graphical abstract: Spectroelectrochemical and computational studies of tetrahydrocannabinol (THC) and carboxy-tetrahydrocannabinol (THC-COOH)

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Supplementary files

Article information


Submitted
29 Oct 2019
Accepted
08 Jan 2020
First published
10 Jan 2020

Analyst, 2020,145, 1849-1857
Article type
Paper

Spectroelectrochemical and computational studies of tetrahydrocannabinol (THC) and carboxy-tetrahydrocannabinol (THC-COOH)

S. D. Bindesri, R. Jebailey, N. Albarghouthi, C. C. Pye and C. L. Brosseau, Analyst, 2020, 145, 1849
DOI: 10.1039/C9AN02173F

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