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Issue 4, 2020
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Current developments in LC-MS for pharmaceutical analysis

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Abstract

Liquid chromatography (LC) based techniques in combination with mass spectrometry (MS) detection have had a large impact on the development of new pharmaceuticals in the past decades. Continuous improvements in mass spectrometry and interface technologies, combined with advanced liquid chromatographic techniques for high-throughput qualitative and quantitative analysis, have resulted in a wider scope of applications in the pharmaceutical field. LC-MS tools are increasingly used to analyze pharmaceuticals across a variety of stages in their discovery and development. These stages include drug discovery, product characterization, metabolism studies (in vitro and in vivo) and the identification of impurities and degradation products. The increase in LC-MS applications has been enormous, with retention times and molecular weights (and related fragmentation patterns) emerging as crucial analytical features in the drug development process. The goal of this review is to give an overview of the main developments in LC-MS based techniques for the analysis of small pharmaceutical molecules in the last decade and give a perspective on future trends in LC-MS in the pharmaceutical field.

Graphical abstract: Current developments in LC-MS for pharmaceutical analysis

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Article information


Submitted
25 Oct 2019
Accepted
15 Jan 2020
First published
16 Jan 2020

Analyst, 2020,145, 1129-1157
Article type
Critical Review

Current developments in LC-MS for pharmaceutical analysis

M. Beccaria and D. Cabooter, Analyst, 2020, 145, 1129
DOI: 10.1039/C9AN02145K

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