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Highly sensitive and selective non-enzymatic glucose detection based on indigo carmine/hemin/H2O2 chemiluminescence

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Abstract

A new chemiluminescence (CL) system, indigo carmine/glucose/hemin/H2O2, has been found and developed for non-enzymatic detection of indigo carmine (IC) and glucose. The CL response increases linearly with IC concentrations from 3.2 μM to 10 mM and glucose concentrations from 0.06 μM to 3.5 mM. The detection limits are 1.45 μM and 15.0 nM for IC and glucose, respectively. This method allows the determination of glucose in blood and urine after simple dilution. The recoveries for the determination of glucose are between 98.5% and 101.0% in blood and between 98.5% and 101.3% in urine. This method shows good sensitivity, selectivity, simplicity, and is low cost, suggesting its promising broad applications.

Graphical abstract: Highly sensitive and selective non-enzymatic glucose detection based on indigo carmine/hemin/H2O2 chemiluminescence

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Article information


Submitted
20 Oct 2019
Accepted
02 Dec 2019
First published
06 Dec 2019

Analyst, 2020, Advance Article
Article type
Paper

Highly sensitive and selective non-enzymatic glucose detection based on indigo carmine/hemin/H2O2 chemiluminescence

T. H. Fereja, S. A. Kitte, M. N. Zafar, M. I. Halawa, S. Han, W. Zhang and G. Xu, Analyst, 2020, Advance Article , DOI: 10.1039/C9AN02100K

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