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Two-dimensional infrared spectroscopy: an emerging analytical tool?

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Abstract

Ultrafast two-dimensional infrared (2D-IR) spectroscopy has provided valuable insights into biomolecular structure and dynamics, but recent progress in laser technology and data analysis methods have demonstrated the potential for high throughput 2D-IR measurements and analytical applications. Using 2D-IR as an analytical tool requires a different approach to data collection and analysis compared to pure research applications however and, in this review, we highlight progress towards usage of 2D-IR spectroscopy in areas relevant to biomedical, pharmaceutical and analytical molecular science. We summarise the technical and methodological advances made to date and discuss the challenges that still face 2D-IR spectroscopy as it attempts to transition from the state-of-the-art laser laboratory to the standard suite of analytical tools.

Graphical abstract: Two-dimensional infrared spectroscopy: an emerging analytical tool?

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Article information


Submitted
11 Oct 2019
Accepted
09 Feb 2020
First published
10 Feb 2020

Analyst, 2020, Advance Article
Article type
Critical Review

Two-dimensional infrared spectroscopy: an emerging analytical tool?

R. Fritzsch, S. Hume, L. Minnes, M. J. Baker, G. A. Burley and N. T. Hunt, Analyst, 2020, Advance Article , DOI: 10.1039/C9AN02035G

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