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Sensitive photoelectrochemical immunoassay of Staphylococcus aureus based on one-pot electrodeposited ZnS/CdS heterojunction nanoparticles

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Abstract

We report here a facile synthesis of ZnS/CdS heterojunction nanoparticles on an indium–tin oxide (ITO) electrode and their application in the ultrasensitive photoelectrochemical detection of Staphylococcus aureus (S. aureus). The ZnS/CdS/ITO electrode was prepared using one-pot electrodeposition in an acidic solution containing ZnCl2, CdCl2 and Na2S2O3. The optimal ZnS/CdS heterojunction nanoparticles with a Zn/Cd atomic ratio of 1 : 1 showed a high photoelectrochemical response to L-cysteine. L-Cysteine-encapsulated liposome (cysteine@liposome) immunonanocapsules were prepared and used as the labels for photoelectrochemical detection of S. aureus. By coupling cysteine@liposome immunonanocapsule labeling with immunomagnetic separation/enrichment and photoelectrochemical analysis using the ZnS/CdS/ITO electrode, sensitive photoelectrochemical detection of S. aureus was achieved. Under optimal conditions, the linear range for photoelectrochemical detection of S. aureus was from 1 to 4000 CFU mL−1. The proposed method was successfully used for photoelectrochemical detection of S. aureus in milk and juice samples.

Graphical abstract: Sensitive photoelectrochemical immunoassay of Staphylococcus aureus based on one-pot electrodeposited ZnS/CdS heterojunction nanoparticles

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Publication details

The article was received on 10 Oct 2019, accepted on 06 Nov 2019 and first published on 14 Nov 2019


Article type: Paper
DOI: 10.1039/C9AN02020A
Analyst, 2020, Advance Article

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    Sensitive photoelectrochemical immunoassay of Staphylococcus aureus based on one-pot electrodeposited ZnS/CdS heterojunction nanoparticles

    H. Yang, X. Zhao, H. Wang, W. Deng, Y. Tan, M. Ma and Q. Xie, Analyst, 2020, Advance Article , DOI: 10.1039/C9AN02020A

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