Optical Biosensors: an exhaustive and comprehensive review
Optical biosensors present good performance in detecting biological systems and promote significant advances in clinical diagnostics, drug discovery, food process control, and environmental monitoring. Without complexity in the pretreatment and probable influence on the nature of target molecules, these biosensors have extra strengths including high sensitivity, robustness, reliability and potential to be integrated in one chip. In this review, the state of the art in optical biosensor technologies, including surface plasmon resonance (SPR), optical waveguide, optical resonator, photonic crystal and optical fiber are presented. Principle in terms of each type of biosensor is introduced concisely and particular emphasis has been placed on the achievements which have been gained nowadays. The strength and weakness of each kind of biosensor have been outlined as well. Concluding remarks regarding the perspectives of further developments are discussed.