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Luminescent gold nanoclusters for in vivo tumor imaging

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Abstract

Fluorescent gold nanoclusters (AuNCs) are emerging as novel imaging contrast agents. These molecules offer excellent prospects for non-invasive tumor diagnosis strategies because of their ultra-small size, tunable emissions from the visible to the near-infrared range, excellent biocompatibility, and suitable pharmacokinetic properties. In this tutorial review, we introduce the physiological features of the tumor microenvironment, followed by a description of AuNC pharmacokinetics. Next, we outline the strategies used to deliver AuNCs specifically to tumor tissues for in vivo tumor imaging. Finally, examples are presented to highlight the application potential of AuNCs for in vivo tumor imaging.

Graphical abstract: Luminescent gold nanoclusters for in vivo tumor imaging

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Publication details

The article was received on 18 Aug 2019, accepted on 19 Nov 2019 and first published on 20 Nov 2019


Article type: Tutorial Review
DOI: 10.1039/C9AN01598A
Analyst, 2020, Advance Article

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    Luminescent gold nanoclusters for in vivo tumor imaging

    H. Li, H. Li and A. Wan, Analyst, 2020, Advance Article , DOI: 10.1039/C9AN01598A

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