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Issue 36, 2020
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Advancements in the development on new liquid embolic agents for use in therapeutic embolisation

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Abstract

Liquid formulations have a well-established role in therapeutic embolisation of blood vessels with the widespread use of cyanoacrylate glues, precipitating polymer suspensions, sclerosing agents and viscous emulsions of oil and chemotherapeutic agents. There is currently an emerging market for next generation liquid embolics which aim to address some of the short-comings of the currently used products. These next generation systems use varying chemistries in their approach to formulate new systems including polymerising, precipitating and phase-transitioning mechanisms to form solidified masses in situ within the vasculature. Some of these emerging technologies have been developed to possess improved imaging properties such as inherent radiopacity, rather than relying on having to mixing with radiopaque materials such as tantalum powder and reduction of X-ray imaging artefacts (streaking). Others offer solvent-free formulations which gel on contact with blood thereby allowing precise control over gel formation during the embolisation process without the use of potentially toxic solvents. In this review, we discuss the role of liquid agents in therapeutic embolisation and the potential of emerging technologies under development for use in the next generation of embolics.

Graphical abstract: Advancements in the development on new liquid embolic agents for use in therapeutic embolisation

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Article information


Submitted
25 Jun 2020
Accepted
07 Aug 2020
First published
07 Aug 2020

This article is Open Access

J. Mater. Chem. B, 2020,8, 8207-8218
Article type
Review Article

Advancements in the development on new liquid embolic agents for use in therapeutic embolisation

J. Lord, H. Britton, S. G. Spain and A. L. Lewis, J. Mater. Chem. B, 2020, 8, 8207 DOI: 10.1039/D0TB01576H

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