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Issue 8, 2020
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Supramolecular and biomacromolecular enhancement of metal-free magnetic resonance imaging contrast agents

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Abstract

Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further overcame the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.

Graphical abstract: Supramolecular and biomacromolecular enhancement of metal-free magnetic resonance imaging contrast agents

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Supplementary files

Article information


Submitted
31 Oct 2019
Accepted
14 Jan 2020
First published
05 Feb 2020

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2020,11, 2045-2050
Article type
Edge Article

Supramolecular and biomacromolecular enhancement of metal-free magnetic resonance imaging contrast agents

H. Lee, A. Shahrivarkevishahi, J. L. Lumata, M. A. Luzuriaga, L. M. Hagge, C. E. Benjamin, O. R. Brohlin, C. R. Parish, H. R. Firouzi, S. O. Nielsen, L. L. Lumata and J. J. Gassensmith, Chem. Sci., 2020, 11, 2045
DOI: 10.1039/C9SC05510J

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    [Original citation] - Published by The Royal Society of Chemistry.

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