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Issue 5, 2020
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Regio- and diastereoselective dearomatizations of N-alkyl activated azaarenes: the maximization of the reactive sites

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Abstract

An unprecedented base-promoted multi-component one-pot dearomatization of N-alkyl activated azaarenes was developed, which enabled the synthesis of complex and diverse bridged cyclic polycycles with multiple stereocenters in a highly regio- and diastereoselective manner. Besides, we realized the step-controlled dearomative bi- and trifunctionalization of quinolinium salts. These transformations not only achieved the maximization of the reaction sites of pyridinium, quinolinium and isoquinolinium salts to enhance structural complexity and diversity, but also opened up a new reaction mode of these N-activated azaarenes. A unique feature of this strategy is the use of easily accessible and bench-stable N-alkyl activated azaarenes to provide maximum reactive sites for dearomative cascade cyclizations. In addition, the salient characteristics including high synthetic efficiency, short reaction time, mild conditions and simple operation made this strategy particularly attractive.

Graphical abstract: Regio- and diastereoselective dearomatizations of N-alkyl activated azaarenes: the maximization of the reactive sites

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Supplementary files

Article information


Submitted
27 Sep 2019
Accepted
17 Dec 2019
First published
17 Dec 2019

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2020,11, 1418-1424
Article type
Edge Article

Regio- and diastereoselective dearomatizations of N-alkyl activated azaarenes: the maximization of the reactive sites

H. Miao, L. Wang, H. Han, Y. Zhao, Q. Wang and Z. Bu, Chem. Sci., 2020, 11, 1418
DOI: 10.1039/C9SC04880D

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