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Issue 32, 2020
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Simultaneously boosting the conjugation, brightness and solubility of organic fluorophores by using AIEgens

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Abstract

Organic near-infrared (NIR) emitters hold great promise for biomedical applications. Yet, most organic NIR fluorophores face the limitations of short emission wavelengths, low brightness, unsatisfactory processability, and the aggregation-caused quenching effect. Therefore, development of effective molecular design strategies to improve these important properties at the same time is a highly pursued topic, but very challenging. Herein, aggregation-induced emission luminogens (AIEgens) are employed as substituents to simultaneously extend the conjugation length, boost the fluorescence quantum yield, and increase the solubility of organic NIR fluorophores, being favourable for biological applications. A series of donor–acceptor type compounds with different substituent groups (i.e., hydrogen, phenyl, and tetraphenylethene (TPE)) are synthesized and investigated. Compared to the other two analogs, MTPE-TP3 with TPE substituents exhibits the reddest fluorescence, highest brightness, and best solubility. Both the conjugated structure and twisted conformation of TPE groups endow the resulting compounds with improved fluorescence properties and processability for biomedical applications. The in vitro and in vivo applications reveal that the NIR nanoparticles function as a potent probe for tumour imaging. This study would provide new insights into the development of efficient building blocks for improving the performance of organic NIR emitters.

Graphical abstract: Simultaneously boosting the conjugation, brightness and solubility of organic fluorophores by using AIEgens

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Supplementary files

Article information


Submitted
20 Jun 2020
Accepted
25 Jul 2020
First published
27 Jul 2020

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2020,11, 8438-8447
Article type
Edge Article

Simultaneously boosting the conjugation, brightness and solubility of organic fluorophores by using AIEgens

J. Qi, X. Duan, Y. Cai, S. Jia, C. Chen, Z. Zhao, Y. Li, H. Peng, R. T. K. Kwok, J. W. Y. Lam, D. Ding and B. Z. Tang, Chem. Sci., 2020, 11, 8438
DOI: 10.1039/D0SC03423A

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