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Issue 7, 2020
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Continuous one-flow multi-step synthesis of active pharmaceutical ingredients

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Abstract

During the past two decades, continuous flow chemistry has been developed into a mature field as shown by numerous examples in which complex molecules are synthesised. In this review we discuss recent one-flow multistep syntheses to produce active pharmaceutical ingredients (APIs) including challenges and solutions that have been encountered.

Graphical abstract: Continuous one-flow multi-step synthesis of active pharmaceutical ingredients

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Article information


Submitted
04 Mar 2020
Accepted
26 May 2020
First published
26 May 2020

This article is Open Access

React. Chem. Eng., 2020,5, 1186-1197
Article type
Review Article

Continuous one-flow multi-step synthesis of active pharmaceutical ingredients

V. R. L. J. Bloemendal, M. A. C. H. Janssen, J. C. M. van Hest and F. P. J. T. Rutjes, React. Chem. Eng., 2020, 5, 1186
DOI: 10.1039/D0RE00087F

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