Issue 56, 2020
From the journal:

RSC Advances

Supermolecule-assisted imaging of low-molecular-weight quaternary-ammonium compounds by MALDI-MS of their non-covalent complexes with cucurbit[7]uril†

Di Chen,ab   Jun Han,*ac   Juncong Yang,a   David Schibli,a   Zhenzhong Zhang ORCID logo b  and  Christoph H. Borchers ORCID logo *defg  

* Corresponding authors

a University of Victoria – Genome British Columbia Proteomics Centre, Victoria, BC V8Z 7X8, Canada
E-mail: HanJun@proteincentre.com

b School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China

c Division of Medical Sciences, University of Victoria, Victoria, BC, Canada

d Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada

e Gerald Bronfman Department of Oncology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
E-mail: christoph.borchers@mcgill.ca

f Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec, Canada

g Center for Computational and Data-Intensive Science and Engineering, Skolkovo Institute of Science and Technology, Moscow 121205, Russia

Abstract

Cucurbit[7]uril was used to form non-covalent complexes with low-molecular-weight quaternary-ammonium compounds for their indirect analysis by MALDI-MS. By shifting the ion signals to a higher and interference-free mass region, the distributions of neurine, choline, and phosphocholine in rat brain were visualized by MALDI imaging with high selectivity and good sensitivity.

Graphical abstract: Supermolecule-assisted imaging of low-molecular-weight quaternary-ammonium compounds by MALDI-MS of their non-covalent complexes with cucurbit[7]uril

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Article information

DOI
https://doi.org/10.1039/D0RA04604C
Article type
Paper
Submitted
25 May 2020
Accepted
08 Sep 2020
First published
15 Sep 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 34261-34265

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Supermolecule-assisted imaging of low-molecular-weight quaternary-ammonium compounds by MALDI-MS of their non-covalent complexes with cucurbit[7]uril

D. Chen, J. Han, J. Yang, D. Schibli, Z. Zhang and C. H. Borchers, RSC Adv., 2020, 10, 34261 DOI: 10.1039/D0RA04604C

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