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Issue 71, 2020, Issue in Progress
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Intra-mitochondrial reaction for cancer cell imaging and anti-cancer therapy by aggregation-induced emission

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Abstract

Controlled intracellular chemical reactions to regulate cellular functions remain a challenge in biology mimetic systems. Herein, we developed an intra-mitochondrial bio-orthogonal reaction to induce aggregation induced emission. In situ carbonyl ligation inside mitochondria drives the molecules to form nano-aggregates with green fluorescence, which leads to depolarization of the mitochondrial membrane, generation of ROS, and subsequently mitochondrial dysfunction. This intra-mitochondrial carbonyl ligation shows great potential for anticancer treatment in various cancer cell lines.

Graphical abstract: Intra-mitochondrial reaction for cancer cell imaging and anti-cancer therapy by aggregation-induced emission

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Supplementary files

Article information


Submitted
31 Aug 2020
Accepted
22 Nov 2020
First published
08 Dec 2020

This article is Open Access

RSC Adv., 2020,10, 43383-43388
Article type
Paper

Intra-mitochondrial reaction for cancer cell imaging and anti-cancer therapy by aggregation-induced emission

S. Kim, J. Kim, B. Jana and J. Ryu, RSC Adv., 2020, 10, 43383
DOI: 10.1039/D0RA07471C

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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    [Original citation] - Published by The Royal Society of Chemistry.

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