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Issue 44, 2020, Issue in Progress
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Design, synthesis, biological evaluation and molecular docking study of novel pyridoxine–triazoles as anti-Alzheimer's agents

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Abstract

A series of multi-target natural product-pyridoxine based derivatives were designed, synthesized, characterized and evaluated as anti-Alzheimer agents. In vitro testing revealed the multi-functional properties of compounds such as inhibition of acetylcholinesterase (AChE), antioxidant and metal chelation. Among the series, 5i derivative was found most potent AChE inhibitor, possess antioxidant potential and chelating metal ions. Further binding interaction of 5i with AChE was studied using molecular docking, showed interaction with both PAS and CAS site of AChE. In silico predictions were also performed to predict toxicity and ADME properties of the molecule 5i and found within drug likeness range. Therefore, 5i could be a promising multi-functional compound that can be used for further development of novel drug for Alzheimer disease.

Graphical abstract: Design, synthesis, biological evaluation and molecular docking study of novel pyridoxine–triazoles as anti-Alzheimer's agents

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Supplementary files

Article information


Submitted
04 Jun 2020
Accepted
03 Jul 2020
First published
09 Jul 2020

This article is Open Access

RSC Adv., 2020,10, 26006-26021
Article type
Paper

Design, synthesis, biological evaluation and molecular docking study of novel pyridoxine–triazoles as anti-Alzheimer's agents

T. Pal, S. Bhimaneni, A. Sharma and S. J. S. Flora, RSC Adv., 2020, 10, 26006
DOI: 10.1039/D0RA04942E

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