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Issue 43, 2020, Issue in Progress
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Thermo-driven self-assembly of a PEG-containing amphiphile in a bilayer membrane

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Abstract

Self-assembly of lipid molecules in a plasma membrane, namely lipid raft formation, is involved in various dynamic functions of cells. Inspired by the raft formation observed in the cells, here we studied thermally induced self-assembly of a synthetic amphiphile, bola-AkDPA, in a bilayer membrane. The synthetic amphiphile consists of a hydrophobic unit including fluorescent aromatic and aliphatic components and hydrophilic tetraethylene glycol chains attached at both ends of the hydrophobic unit. In a polar solvent, bola-AkDPA formed aggregates to show excimer emission. In a lipid bilayer membrane, bola-AkDPA showed intensified excimer emission upon increase of its concentration or elevation of the temperature; bola-type amphiphiles containing oligoethylene glycol chains likely tend to form self-assemblies in a bilayer membrane triggered by thermal stimuli.

Graphical abstract: Thermo-driven self-assembly of a PEG-containing amphiphile in a bilayer membrane

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Article information


Submitted
01 May 2020
Accepted
01 Jul 2020
First published
07 Jul 2020

This article is Open Access

RSC Adv., 2020,10, 25758-25762
Article type
Paper

Thermo-driven self-assembly of a PEG-containing amphiphile in a bilayer membrane

R. Li, T. Muraoka and K. Kinbara, RSC Adv., 2020, 10, 25758
DOI: 10.1039/D0RA03920A

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