Issue 27, 2020

Enabling protein-hosted organocatalytic transformations


In this review, the development of organocatalytic artificial enzymes will be discussed. This area of protein engineering research has underlying importance, as it enhances the biocompatibility of organocatalysis for applications in chemical and synthetic biology research whilst expanding the catalytic repertoire of enzymes. The approaches towards the preparation of organocatalytic artificial enzymes, techniques used to improve their performance (selectivity and reactivity) as well as examples of their applications are presented. Challenges and opportunities are also discussed.

Graphical abstract: Enabling protein-hosted organocatalytic transformations

Article information

Article type
Review Article
17 Feb 2020
25 Mar 2020
First published
23 Apr 2020
This article is Open Access
Creative Commons BY license

RSC Adv., 2020,10, 16147-16161

Enabling protein-hosted organocatalytic transformations

A. R. Nödling, N. Santi, T. L. Williams, Y. Tsai and L. Y. P. Luk, RSC Adv., 2020, 10, 16147 DOI: 10.1039/D0RA01526A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity