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Issue 7, 2020
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Nickel-doped cerium oxide nanoparticles: biosynthesis, cytotoxicity and UV protection studies

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Abstract

This study was conducted to obtain NixCe1−xO2 (where x = 0, 1, 3 and 5% w/w) nanoparticles using Salvadora persica extracts through an easy, inexpensive and non-toxic method. The biosynthesized nanoparticles have been characterized via powder X-ray diffraction (PXRD), Raman spectroscopy, field emission scanning electron microscopy (FESEM), energy dispersive X-ray (EDX) spectroscopy, and vibrating-sample magnetometer (VSM) analysis. The results of PXRD showed that Ni doping in the CeO2 process generated a higher shift at an angle of (111); also, the PXRD patterns were surveyed by the Rietveld refinement technique. Raman analysis revealed that doping nickel in CeO2 led to the nanoparticles reducing the intensity of the F2g mode. The FESEM images showed that the particle size was 5–6 nm and it had a spherical shape. The hysteresis loops of the synthesized nanoparticles were similar to that of the normal ferromagnetic materials. The cytotoxic activity of the synthesized undoped and Ni-doped CeO2-NPs was determined using MTT assays against a colon cancer cell line (HT-29). The results showed that the cytotoxic effect of the synthesized nanoparticles changed after doping nickel in CeO2-NPs. The increase in the Ni-doping value for CeO2-NPs increased the cytotoxic activity. The sun protection factor (SPF) has been estimated through spectrophotometric measurements for determining UV protection. This showed that increasing the percentage of nickel in the doped nanoparticles increased the protection factor and a higher SPF value was obtained: 48.52.

Graphical abstract: Nickel-doped cerium oxide nanoparticles: biosynthesis, cytotoxicity and UV protection studies

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Submitted
03 Nov 2019
Accepted
06 Jan 2020
First published
23 Jan 2020

This article is Open Access

RSC Adv., 2020,10, 3967-3977
Article type
Paper

Nickel-doped cerium oxide nanoparticles: biosynthesis, cytotoxicity and UV protection studies

A. Miri, M. Sarani and M. Khatami, RSC Adv., 2020, 10, 3967
DOI: 10.1039/C9RA09076B

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