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Issue 2, 2020
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Effects of an isatin derivative on tumor cell migration and angiogenesis

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Abstract

Compound 5-61, a 5-(2-carboxyethenyl)isatin derivative was previously shown to have potent anticancer activity. Its effect on angiogenesis was further explored in this study. Notably, 5-61 showed selective cytotoxicity against liver hepatocellular carcinoma HepG-2 cells (IC50 = 7.13 nM). 5-61 powerfully induced apoptosis and G2/M phase arrest as well as inhibited the migration of HepG2 cells. Additionally, 5-61 clearly diminished tube formation and the actin arrangement in HUVECs. The physiological anti-angiogenic effects of 5-61 were further assessed by chick chorioallantoic membrane assays in vivo. The effects exerted by 5-61 were found to be mediated by VEGF along with its downstream signaling pathways including the PI3K/Akt/mTOR pathway and mitogen-activate protein kinase pathways (ERK). These results suggested that 5-61 is a potential tumor angiogenesis inhibitor that functions by interrupting the auto-phosphorylation of AKT, mTOR, and ERK 1/2.

Graphical abstract: Effects of an isatin derivative on tumor cell migration and angiogenesis

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Article information


Submitted
16 Oct 2019
Accepted
12 Dec 2019
First published
08 Jan 2020

This article is Open Access

RSC Adv., 2020,10, 1191-1197
Article type
Paper

Effects of an isatin derivative on tumor cell migration and angiogenesis

Y. Chang, Y. Yuan, Q. Zhang, Y. Rong, Y. Yang, M. Chi, Z. Liu, Y. Zhang, P. Yu and Y. Teng, RSC Adv., 2020, 10, 1191
DOI: 10.1039/C9RA08448G

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