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Issue 2, 2021
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Synthetic developments on the preparation of sulfides from thiol-free reagents

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Abstract

Thiols are known for their strong odor and high toxicity, which makes the development of thiol-free alternatives for the construction of sulfur-containing derivatives, in particular sulfides (thioethers), highly desirable. Over the last few years, several approaches for the preparation of these compounds from alternative sources, such as DMSO, disulfides, elemental sulfur, Bunte salts, and N-substituted sulfanylsuccinimides, have been described. This critical review presents an in-depth analysis of the preparation of these derivatives, including the presentation of selected examples and the careful discussion of mechanistic pathways.

Graphical abstract: Synthetic developments on the preparation of sulfides from thiol-free reagents

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Article information


Submitted
07 Oct 2020
Accepted
11 Nov 2020
First published
12 Nov 2020

Org. Chem. Front., 2021,8, 326-368
Article type
Review Article

Synthetic developments on the preparation of sulfides from thiol-free reagents

G. M. F. Batista, P. P. de Castro, J. A. dos Santos, T. Skrydstrup and G. W. Amarante, Org. Chem. Front., 2021, 8, 326
DOI: 10.1039/D0QO01226B

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